genotoxic stress การใช้

• This interaction is increased by genotoxic stress.
• In cells depleted of FBXO31, MDM2 is not degraded and p53 levels do not increase following genotoxic stress.
• LAPTM4B promotes autophagy and renders tumor cells resistant to metabolic and genotoxic stress and results in more rapid tumor growth.
• Following genotoxic stress, FBXO31 is phosphorylated by the DNA damage serine / threonine kinase ATM, resulting in increased levels of FBXO31.
• Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are mainly important in the context of genotoxic stress.
• It is suggested that GLS1 s control of ROS levels facilitates  the ability of p53 to protect cells from accumulation of genomic damage and allows cells to survive after mild and repairable genotoxic stress . 
• Sinclair is also credited with the " Mitochondrial Oasis Hypothesis " which states that the energetics and NAD + content of mitochondria determines cell survival in the face of genotoxic stress ( i . e . DNA damage ), independent of the state of the cytoplasm or nucleus.
• F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress . the F-box protein FBXO31, a candidate tumor suppressor encoded in 16q24.3 for which there is loss of heterozygosity in various solid tumors, is responsible for promoting MDM2 degradation.
• MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response.
• A first group of protein kinases belongs to the MAPK family ( JNK1-3, ERK1-2, p38 MAPK ), which is known to respond to several types of stress, such as membrane damage, oxidative stress, osmotic shock, heat shock, etc . A second group of protein kinases ( DNA-PK, CAK, TP53RK ) is implicated in the genome integrity checkpoint, a molecular cascade that detects and responds to several forms of DNA damage caused by genotoxic stress.